Many VOC such as acrolein, propylene oxide, and benzene are metabolized by the glutathione S-transferase pathway leading to the excretion of mercapturic acids in urine; these metabolites can be quantified. Virtually all urine samples will contain these metabolites, but levels in exposed subjects may be significantly higher. For more details see Exposure to Volatile Organic Compounds (VOC)
Biospecimens: Volume Requirements - few mL of urine for Mercapturic Acids;
Core analytes (subset of analytes that will be measured and reported by any targeted HHEAR Lab Hub that provides Volatile Organic Compound Metabolites in urine):
- 2-Cyanoethylmercapturic acid
- 2-Hydroxyethylmercapturic acid
- 2-Hydroxypropylmercapturic acid
- 3-Hydroxypropylmercapturic acid
- S-Phenylmercapturic acid
Other Volatile Organic Compound Metabolites analytes (analytes that can also be measured depending on the Lab Hub and the requested analytes) include but are not limited to:
- 2-Carbonamideethylmercapturic acid
- 3,4-Dihydroxybutylmercapturic acid
- 3-hydroxy-1-methylpropyl mercapturic acid
- 3-hydroxy-2-methylpropyl mercapturic acid
- 3-hydroxy-3-methylpropyl mercapturic acid