Exposure to PBDE and other BFR can be measured by quantifying the parent chemicals or their metabolites in plasma, serum or urine, or in environmental samples, such as house dust or wristbands. For more details see Exposure to Brominated Flame Retardants (BFR).
Biospecimens: Volume requirements – typically up to 1 mL of plasma or serum
Core analytes (subset of analytes that will be measured and reported by any targeted HHEAR Lab Hub that provides BFR analysis in urine, plasma, or serum):
- 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE 209)
- 2,2',3,4,4',5',6-Heptabromodiphenyl ether (BDE 183)
- 2,2',4,4',5,5'-Hexabromobiphenyl (PBB153)
- 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE 153)
- 2,2',4,4',5,6'-Hexabromodiphenyl ether (BDE 154)
- 2,2',3,4,4'-Pentabromodiphenyl ether (BDE 85)
- 2,2',4,4',5-Pentabromodiphenyl ether (BDE 99)
- 2,2',4,4',6-Pentabromodiphenyl ether (BDE 100)
- 2,2',4,4'-Tetrabromodiphenyl ether (BDE 47)
- 2,3',4,4'-Tetrabromodiphenyl ether (BDE 66)
- 2,2',4'-Tribromodiphenyl ether (BDE 17)
- 2,4,4'-Tribromodiphenyl ether (BDE 28)
- 2,3,4,5-Tetrabromobenzoic acid (TBBA) – urine matrix only
Environmental Samples: Volume requirements – for most analytes 500 milligrams of dust is sufficient
- 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE 209)
- 2,2',3,4,4',5',6-Heptabromodiphenyl ether (BDE 183)
- 2,2',3,4,4'-Pentabromodiphenyl ether (BDE 85)
- 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE 153)
- 2,2',4,4',5,6'-Hexabromodiphenyl ether (BDE 154)
- 2,2',4,4',5-Pentabromodiphenyl ether (BDE 99)
- 2,2',4,4',6-Pentabromodiphenyl ether (BDE 100)
- 2,2',4,4'-Tetrabromodiphenyl ether (BDE 47)
- 2,2',4'-Tribromodiphenyl ether (BDE 17)
- 2,3',4,4'-Tetrabromodiphenyl ether (BDE 66)
- 2,4,4'-Tribromodiphenyl ether (BDE 28)
- 2-ethyl hexyl-2,3,4,5-tetrabromobenzoate (TBB)
- Bis (2-ethyl hexyl)-2,3,4,5-tetrabromophthalate (TBPH)
- Bistribromophenoxyethane (BTBPE)
- Tetrabromobisphenol A (TBBPA)
- Tris (2,3-dibromopropyl) isocyanurate (TDBPIC)