Analytes for Exposure to DNA-Damaging Agents

DNA damage can be measured by quantifying DNA adducts with highly-sensitive liquid chromatography-mass spectrometry (LC-MS) assays. For more details see Exposure to DNA-Damaging Agents.

Formaldehyde-DNA adducts 10 µg DNA
Acetaldehyde-DNA adducts 1 µg DNA
Acrolein-DNA adducts 10 µg DNA
Methylglyoxal-DNA adducts 10 µg DNA
DNA adducts of Heterocyclic aromatic amines and 4-aminobiphenyl (4-ABP) DNA 10 µg DNA
DNA adducts of aristolochic acid 10 µg DNA
7-ethylguanine 5 ml of blood
7-phenylguanine 20 ml of blood
7-carboxyethylguanine 10 ml of blood
DNA adducts of 4-ABP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), other heterocyclic aromatic amines (HAAs) 10 µg DNA
DNA adducts of Aristolochic Acid, 4-ABP, PhIP, other HAAs 10 µg DNA
3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) 30 µg DNA
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and 8-oxo-7,8-dihydro-2ʹ-deoxyadenosine (8-oxo-dA) 50 ng DNA